Juvenile localized scleroderma: review of 44 patients

Results 70.5% of patients were females. CM (34.1%) and LM (34.1%) were the most frequently subtypes. Mean age at first symptoms was 7.7 years (Figure 1). Medium time between first signs/symptoms and diagnosis was 15.42 months. One patient with CM head-neck lesions had Parry-Romberg disease with neurological involvement. 50% of patients with head-neck LM had “coup de sabre” subtype, 25% of that with neurological involvement. One patient had joint movement limitation and another limb dysmetria. 38.6% patients tested positive for ANA, none developed SLE. Scl-70 and anticentromere were negative in all. Drugs most frequently used were topical corticosteroids (61.3%), methotrexate and systemic corticosteroids (38.6%) and topical tacrolimus (36.4%). Time to remission was 6.95 months. 34.09% of patients had clinical relapse, 26.6% of these being on treatment.